Blocking the uptake of large amounts of cholesterol into brain cancer cells could provide a new strategy to battle glioblastoma, one of the most deadly brain malignancies, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.
The study, done using cells lines, mouse models and an analysis of tissue from brain cancer patients, uncovered a novel mechanism by which the most commonly activated oncogene, the mutated epidermal growth factor receptor (EGFR), overcomes normal... [+]